Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC048
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-12 09:17
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment madopar 3x1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 21, 'TN': 17, 'TP': 21, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 5, 'TN': 2, 'TP': 37, 'FP': 28}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 5, 'TP': 37, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 4.948
timePerCircleCoV 0.23744
timePerCircleSlope -0.0636437
meanError 2.0692
tremorFreq 5.56641
tremorRelPower 29.9241
tremorGyroAmpMean 0.0291734
tremorGyroAmpSlope 0.0137907
tremorGyroAmpCoV 0.397433
tremorCoordAmpMean 0.0618368
tremorCoordAmpSlope 0.0137845
tremorCoordAmpCoV 0.323459
tremorAccAmpMean 0.0717359
tremorAccAmpSlope 0.0108091
tremorAccAmpCoV 0.287182
tremorPcRelVar 0.844644
tremorPcX -0.565003
tremorPcY 0.825089

Circle Segment 1

Duration 6.92 s, Accuracy Estimate 1.843 (lower is better)

Circle Segment 2

Duration 6.88 s, Accuracy Estimate 2.161 (lower is better)

Circle Segment 3

Duration 5.4 s, Accuracy Estimate 1.993 (lower is better)

Circle Segment 4

Duration 5.44 s, Accuracy Estimate 1.592 (lower is better)

Circle Segment 5

Duration 4.08 s, Accuracy Estimate 1.942 (lower is better)

Circle Segment 6

Duration 3.84 s, Accuracy Estimate 2.312 (lower is better)

Circle Segment 7

Duration 4.44 s, Accuracy Estimate 1.872 (lower is better)

Circle Segment 8

Duration 3.88 s, Accuracy Estimate 1.867 (lower is better)

Circle Segment 9

Duration 4.04 s, Accuracy Estimate 2.147 (lower is better)

Circle Segment 10

Duration 4.56 s, Accuracy Estimate 2.963 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 13.968
timePerSpiralCoV 0.104644
timePerSpiralSlope -0.0162449
meanError 2.67308
tremorFreq 5.46875
tremorRelPower 27.7078
tremorGyroAmpMean 0.034252
tremorGyroAmpSlope 0.00203732
tremorGyroAmpCoV 0.300184
tremorCoordAmpMean 0.0787199
tremorCoordAmpSlope 0.00336336
tremorCoordAmpCoV 0.303387
tremorAccAmpMean 0.0729238
tremorAccAmpSlope 0.00336938
tremorAccAmpCoV 0.300054
tremorPcRelVar 0.877125
tremorPcX -0.40274
tremorPcY 0.915314

Spiral Segment 1

Duration 17.84 s, Accuracy Estimate 2.319 (lower is better)

Spiral Segment 2

Duration 13.88 s, Accuracy Estimate 2.436 (lower is better)

Spiral Segment 3

Duration 12.72 s, Accuracy Estimate 2.084 (lower is better)

Spiral Segment 4

Duration 13.44 s, Accuracy Estimate 2.21 (lower is better)

Spiral Segment 5

Duration 13.4 s, Accuracy Estimate 2.495 (lower is better)

Spiral Segment 6

Duration 13.56 s, Accuracy Estimate 5.125 (lower is better)

Spiral Segment 7

Duration 14.16 s, Accuracy Estimate 2.44 (lower is better)

Spiral Segment 8

Duration 14.24 s, Accuracy Estimate 2.643 (lower is better)

Spiral Segment 9

Duration 13.8 s, Accuracy Estimate 2.498 (lower is better)

Spiral Segment 10

Duration 12.64 s, Accuracy Estimate 2.482 (lower is better)

Elel

eDurationMean 0.686795
eDurationStd 0.101414
eDurationStdnorm 0.147663
eDurationMedian 0.67
eDurationQuartdelta 0.12625
eDurationQuartdeltanorm 0.188433
eDurationKurt 3.96107
eDurationTrenddiff -0.04
eDurationTrendratio 0.941176
eWidthMean 4.902
eWidthStd 1.14094
eWidthStdnorm 0.23275
eWidthMedian 4.68
eWidthQuartdelta 1.49175
eWidthQuartdeltanorm 0.31875
eWidthKurt 3.31167
eWidthTrenddiff -0.468
eWidthTrendratio 0.902439
eHeightMean 11.562
eHeightStd 1.7766
eHeightStdnorm 0.153658
eHeightMedian 11.583
eHeightQuartdelta 2.42775
eHeightQuartdeltanorm 0.209596
eHeightKurt 2.83548
eHeightTrenddiff -1.989
eHeightTrendratio 0.844037
eAspectMean 0.429295
eAspectStd 0.0969432
eAspectStdnorm 0.22582
eAspectMedian 0.406593
eAspectQuartdelta 0.103851
eAspectQuartdeltanorm 0.255417
eAspectKurt 3.45177
eAspectTrenddiff 0.0467507
eAspectTrendratio 1.11538
eSlantMean -0.148823
eSlantStd 0.135135
eSlantStdnorm -0.908021
eSlantMedian -0.153846
eSlantQuartdelta 0.232138
eSlantQuartdeltanorm -1.5089
eSlantKurt 2.00734
eSlantTrenddiff -0.0566416
eRtopMean 0.719911
eRtopStd 0.0994816
eRtopStdnorm 0.138186
eRtopMedian 0.72093
eRtopQuartdelta 0.135812
eRtopQuartdeltanorm 0.188385
eRtopKurt 2.54965
eRtopTrenddiff 0.0455192
eRbotMean 1.10641
eRbotStd 0.36565
eRbotStdnorm 0.330483
eRbotMedian 1.03571
eRbotQuartdelta 0.456737
eRbotQuartdeltanorm 0.440988
eRbotKurt 2.66441
eRbotTrenddiff 0.0877193
eRrightMean 0.816276
eRrightStd 0.0961888
eRrightStdnorm 0.117839
eRrightMedian 0.818182
eRrightQuartdelta 0.0988957
eRrightQuartdeltanorm 0.120873
eRrightKurt 5.52431
eRrightTrenddiff 0.0125139
eRleftMean 0.489078
eRleftStd 0.0870015
eRleftStdnorm 0.177889
eRleftMedian 0.495146
eRleftQuartdelta 0.126913
eRleftQuartdeltanorm 0.256314
eRleftKurt 3.31695
eRleftTrenddiff 0.0197564
lDurationMean 0.822237
lDurationStd 0.15199
lDurationStdnorm 0.184849
lDurationMedian 0.805
lDurationQuartdelta 0.175
lDurationQuartdeltanorm 0.217391
lDurationKurt 8.00721
lDurationTrenddiff -0.065
lDurationTrendratio 0.924419
lWidthMean 4.62458
lWidthStd 1.19619
lWidthStdnorm 0.258658
lWidthMedian 4.2705
lWidthQuartdelta 1.638
lWidthQuartdeltanorm 0.383562
lWidthKurt 4.95326
lWidthTrenddiff -0.702
lWidthTrendratio 0.85
lHeightMean 17.3837
lHeightStd 1.78699
lHeightStdnorm 0.102797
lHeightMedian 16.965
lHeightQuartdelta 2.808
lHeightQuartdeltanorm 0.165517
lHeightKurt 2.63641
lHeightTrenddiff -1.521
lHeightTrendratio 0.915584
lAspectMean 0.267819
lAspectStd 0.0675825
lAspectStdnorm 0.252344
lAspectMedian 0.251851
lAspectQuartdelta 0.0754932
lAspectQuartdeltanorm 0.299754
lAspectKurt 3.01433
lAspectTrenddiff -0.0371763
lAspectTrendratio 0.866165
lSlantMean -0.212744
lSlantStd 0.125948
lSlantStdnorm -0.592016
lSlantMedian -0.205548
lSlantQuartdelta 0.161978
lSlantQuartdeltanorm -0.78803
lSlantKurt 2.51686
lSlantTrenddiff 0.00865703
lRtopMean 0.656241
lRtopStd 0.168978
lRtopStdnorm 0.257493
lRtopMedian 0.632468
lRtopQuartdelta 0.184028
lRtopQuartdeltanorm 0.290968
lRtopKurt 3.46832
lRtopTrenddiff -0.0923913
lRbotMean 1.50225
lRbotStd 0.508674
lRbotStdnorm 0.338608
lRbotMedian 1.45357
lRbotQuartdelta 0.7125
lRbotQuartdeltanorm 0.490172
lRbotKurt 2.51237
lRbotTrenddiff 0.285285
lRrightMean 0.78922
lRrightStd 0.112582
lRrightStdnorm 0.14265
lRrightMedian 0.795994
lRrightQuartdelta 0.167212
lRrightQuartdeltanorm 0.210067
lRrightKurt 2.78572
lRrightTrenddiff -0.00294781
lRleftMean 0.496107
lRleftStd 0.130691
lRleftStdnorm 0.263433
lRleftMedian 0.501572
lRleftQuartdelta 0.197394
lRleftQuartdeltanorm 0.393551
lRleftKurt 2.26648
lRleftTrenddiff 0.00314465

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.932447
sumTouchScores 26.1085
meanMovementTime 0.628889
numTouches 28
undershootPercentage 0
overshootPercentage 10.7143

FITTS Long Modified

meanTouchScore 0.849047
sumTouchScores 18.679
meanMovementTime 0.836429
numTouches 22
undershootPercentage 4.54545
overshootPercentage 27.2727

ZigZag

numZigzags 5
timePerZigzagMean 13.328
timePerZigzagCoV 0.0862134
timePerZigzagSlope -0.0429172
meanError 2.38079
tremorFreq 5.76172
tremorRelPower 26.6485
tremorGyroAmpMean 0.0350707
tremorGyroAmpSlope 0.00524812
tremorGyroAmpCoV 0.363404
tremorCoordAmpMean 0.0899889
tremorCoordAmpSlope 0.00174744
tremorCoordAmpCoV 0.246682
tremorAccAmpMean 0.117457
tremorAccAmpSlope 0.00107395
tremorAccAmpCoV 0.153647
tremorPcRelVar 0.771827
tremorPcX -0.617002
tremorPcY -0.786962

ZigZag Segment 1

Duration 15.32 s, Accuracy Estimate 2.177 (lower is better)

ZigZag Segment 2

Duration 12.92 s, Accuracy Estimate 2.156 (lower is better)

ZigZag Segment 3

Duration 13.24 s, Accuracy Estimate 2.625 (lower is better)

ZigZag Segment 4

Duration 12.48 s, Accuracy Estimate 2.565 (lower is better)

ZigZag Segment 5

Duration 12.68 s, Accuracy Estimate 2.381 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.76
timePerZigzagCoV 0.164763
timePerZigzagSlope -0.0507837
zigzagHeightMean 88.6502
zigzagHeightCoV 0.0758464
zigzagHeightSlope 0.0411583
meanError 0.085831
tremorFreq 5.95703
tremorRelPower 25.3569
tremorGyroAmpMean 0.0351993
tremorGyroAmpSlope -0.00189613
tremorGyroAmpCoV 0.37192
tremorCoordAmpMean 0.0785214
tremorCoordAmpSlope 0.000263977
tremorCoordAmpCoV 0.285199
tremorAccAmpMean 0.066901
tremorAccAmpSlope -0.000449779
tremorAccAmpCoV 0.357504
tremorPcRelVar 0.791192
tremorPcX 0.554564
tremorPcY -0.832141

ZigZag Offset Segment 1

Duration 15.6 s, Accuracy Estimate 0.079 (lower is better)

ZigZag Offset Segment 2

Duration 12.68 s, Accuracy Estimate 0.052 (lower is better)

ZigZag Offset Segment 3

Duration 11.84 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 4

Duration 9.96 s, Accuracy Estimate 0.116 (lower is better)

ZigZag Offset Segment 5

Duration 13.72 s, Accuracy Estimate 0.123 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.73}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.8550183474321273}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9337953337680103}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}